John A Tainer Selected Research

Enzymes

1/2021	Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.
1/2021	A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.
12/2020	Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
1/2019	RNA Modifications: Reversal Mechanisms and Cancer.
1/2017	Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
7/2014	The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.
4/2010	Substrate recognition and catalysis by flap endonucleases and related enzymes.
4/2009	Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
4/2007	The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John A Tainer Research Topics

Disease

56	Neoplasms (Cancer) 05/2024 - 07/2003
19	Genomic Instability 01/2023 - 11/2004
7	Infections 01/2024 - 07/2003
6	Breast Neoplasms (Breast Cancer) 05/2024 - 09/2003
5	Carcinogenesis 01/2021 - 07/2008
5	Ataxia Telangiectasia (Louis Bar Syndrome) 04/2011 - 08/2007
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 02/2009 - 11/2002
3	Bites and Stings (Sting) 04/2024 - 01/2021
3	Xeroderma Pigmentosum (Kaposi's Disease) 01/2022 - 01/2019
3	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2018
3	Nijmegen Breakage Syndrome 01/2018 - 08/2007
3	Werner Syndrome (Werner's Syndrome) 06/2011 - 05/2006
3	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2009 - 09/2003
3	Dehydration (Water Stress) 03/2006 - 10/2003
2	Trichothiodystrophy Syndromes 01/2023 - 01/2019
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2019 - 02/2009
2	Cockayne Syndrome (Syndrome, Cockayne) 01/2019 - 10/2005
2	Inflammation (Inflammations) 04/2016 - 11/2008
2	Virus Diseases (Viral Diseases) 06/2012 - 01/2011
2	Premature Aging 06/2011 - 05/2006
1	Pancreatic Neoplasms (Pancreatic Cancer) 04/2024
1	Human Influenza (Influenza) 01/2024
1	Hypoxia (Hypoxemia) 01/2022
1	Hyperthermia 01/2022
1	Adenocarcinoma of Lung 01/2021
1	Autism Spectrum Disorder 01/2021
1	Autistic Disorder (Autism) 01/2021
1	COVID-19 01/2021

Drug/Important Bio-Agent (IBA)

30	DNA (Deoxyribonucleic Acid)IBA 04/2024 - 11/2004
23	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2003
10	Phosphotransferases (Kinase)IBA 04/2024 - 08/2007
9	EnzymesIBA 01/2021 - 04/2007
6	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 08/2021 - 10/2009
5	UbiquitinIBA 04/2016 - 09/2007
5	Superoxide DismutaseIBA 04/2009 - 11/2002
4	RNA (Ribonucleic Acid)IBA 05/2024 - 01/2011
4	Poly(ADP-ribose) Polymerase InhibitorsIBA 03/2024 - 12/2019
4	Ligases (Synthetase)IBA 11/2021 - 09/2007
4	Flap EndonucleasesIBA 01/2017 - 04/2010
3	Adenosine Triphosphatases (ATPase)IBA 10/2023 - 04/2011
3	Adenosine Triphosphate (ATP)IBA 01/2023 - 04/2011
3	A-Form DNA (A-DNA)IBA 03/2022 - 05/2014
3	B-Form DNA (B-DNA)IBA 01/2022 - 01/2016
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 12/2015
3	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2021 - 12/2010
3	EndonucleasesIBA 01/2020 - 04/2010
3	Superoxide Dismutase-1IBA 10/2014 - 11/2002
3	Alkyl and Aryl TransferasesIBA 11/2010 - 08/2007
2	Immune Checkpoint InhibitorsIBA 04/2024 - 01/2021
2	Peptides (Polypeptides)IBA 04/2024 - 03/2006
2	InterferonsIBA 04/2024 - 01/2021
2	CytokinesIBA 03/2024 - 01/2021
2	Novobiocin (Streptonivicin)FDA Link 10/2023 - 01/2021
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 04/2009
2	Oxygen (Dioxygen)IBA 11/2021 - 10/2003
2	ChromatinIBA 11/2021 - 01/2020
2	poly ADP-ribose glycohydrolaseIBA 01/2021 - 12/2019
2	CollagenIBA 01/2021 - 01/2018
2	PhosphopeptidesIBA 01/2018 - 08/2007
2	Phosphates (Orthophosphate)IBA 01/2017 - 01/2017
2	CopperIBA 10/2014 - 11/2007
2	Cysteine (L-Cysteine)FDA Link 11/2010 - 06/2009
2	Exonucleases (3' 5' Exonuclease)IBA 08/2010 - 05/2006
2	O(6)-Methylguanine-DNA MethyltransferaseIBA 06/2009 - 08/2007
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 05/2024
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 04/2024
1	Mitochondrial DNA (mtDNA)IBA 04/2024
1	Toll-Like Receptor 9IBA 04/2024
1	nardilysinIBA 04/2024
1	Antiviral Agents (Antivirals)IBA 01/2024
1	lariat debranching enzymeIBA 01/2023
1	Rad51 RecombinaseIBA 01/2023
1	CamptothecinIBA 03/2022
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 03/2022
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 03/2022
1	Replication Protein AIBA 01/2022
1	Staphylococcal Protein A (Protein A)IBA 01/2022
1	Protein Tyrosine PhosphatasesIBA 01/2022
1	Vitamin E FDA LinkGeneric 01/2022
1	Biomarkers (Surrogate Marker)IBA 08/2021
1	Cisplatin (Platino)FDA LinkGeneric 01/2021
1	Protein Kinases (Protein Kinase)IBA 01/2021
1	2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)IBA 01/2021
1	Adenosine Diphosphate Ribose (ADP-Ribose)IBA 01/2021
1	Pemetrexed (MTA)FDA Link 01/2021
1	DNA-Activated Protein KinaseIBA 01/2021
1	VaccinesIBA 01/2021
1	Floxuridine (FUdR)FDA LinkGeneric 01/2021
1	Fluorouracil (Carac)FDA LinkGeneric 01/2021
1	UracilIBA 01/2021
1	UDP glucose-collagen glucosyltransferase (procollagen glucosyltransferase)IBA 01/2021
1	Glycoside Hydrolases (Endoglycosidases)IBA 01/2021
1	HeterochromatinIBA 01/2021
1	high density lipoprotein binding proteinIBA 01/2021
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021

Therapy/Procedure

9	Therapeutics 05/2024 - 07/2006
7	Drug Therapy (Chemotherapy) 01/2021 - 08/2004
2	Ligation 03/2022 - 08/2015
2	Immunotherapy 01/2022 - 01/2021
1	Traction 01/2022